Andy Carroll has withdrawn from England's World Cup qualifiers against Moldova and Ukraine next week because of a hamstring injury.
The 23-year-old striker, who joined West Ham in a loan deal from Liverpool on Friday, made an impressive debut as the Hammers beat Fulham 3-0.
Carroll limped out of the action on 68 minutes at Upton Park.
The Football Association will wait until after Sunday's games before deciding on how to replace Carroll.
Following his side's win, West Ham boss Sam Allardyce said it was "unlikely" Carroll would be fit.
"He'll probably be on the treatment bench for a while," said Allardyce.
"He over-extended himself. We won't know the extent of the injury until the scan and we see how serious it is."
England's road to Brazil 2014 begins with a qualifier at the Zimbru Stadium in Moldova on Friday 7 September and Roy Hodgson's side are back in action at Wembley against Ukraine on 11 September.
Allardyce added: "We were ready to bring him off and unfortunately on that last jump he got hit by Brede Hangeland and that twisted his body and pulled his hamstring by the looks of it.
"He is just so gutted because he has got injured and he can't go to England, that is why he is most disappointed because he wanted to get off there.
"We are going to play him and hopefully he will play every week for us and score goals and obviously Roy Hodgson is going to pick him - he wants to do well for us and he wants to do well for England."
Carroll has joined West Ham on a season-long loan from Liverpool and played a key part in two of his new side's goals against the Cottagers.
Allardyce added: "I think what is important is the delight of everybody when Andy walked through the door.
"I think it made us all feel that little bit better when you have got a £35m centre-forward walk through the door whether you have got him on loan or not.
"He is a quality centre-forward and he is our number one. We can hopefully play to his strength and he can hopefully help us do what we want to do.
"It brought excitement to Kevin Nolan's performance because Kevin can feed off Andy instinctively very, very well.
"Kevin could have probably had a hat-trick today because if he knows the ball is going to Andy he knows he can go beyond and get into areas where Andy can find him.
"I know people will point at his aerial strength, and he is one of the best headers of the ball in the Premier League, but he is a fine all round player too."
Great news that



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